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mtx 531  (MedChemExpress)


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    MedChemExpress mtx 531
    A-B, D-E, G-H. Plots showing the percentage of anastasis normalized to the control in cells treated 5h with 150ng/ml (A, D, G) or 250ng/ml DOX (B, E, H), and washed with different concentrations of the Akt inhibitor ALM301 (A, B), the PI3K inhibitor LY29004 (D, E), or the dual EGFR/PI3K <t>inhibitor</t> <t>MTX-531</t> (G, H). Although 100µM MTX-531 is the most lethal condition, the plotted curve does not fully capture this effect because extensive cell death led to aggregation, which interfered with accurate detection of anastatic cells and artificially increased their measured frequency (G-H, *Artifact). Different treatments are shown in distinct colors. The positive control (qVD-Oph) is shown in black. Data were normalized by subtraction. Data and error bars were smoothed. Error bars represent the mean ± SD from n=2 independent experiments. C. Plot showing the percentage confluence normalized to its initial value in cells that were not exposed to DOX for ALM301 treatment. F, I. Images comparing the effects of 10µM and 100µM LY294002 (F) or MTX-531 (I) and the corresponding DMSO controls in cells that were not exposed to DOX at the end of our experiment.
    Mtx 531, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 94/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/mtx 531/product/MedChemExpress
    Average 94 stars, based on 1 article reviews
    mtx 531 - by Bioz Stars, 2026-03
    94/100 stars

    Images

    1) Product Images from "A kinome inhibitor screen implicates adhesion and growth factor signaling in cellular recovery after caspase activation"

    Article Title: A kinome inhibitor screen implicates adhesion and growth factor signaling in cellular recovery after caspase activation

    Journal: bioRxiv

    doi: 10.64898/2026.01.06.697929

    A-B, D-E, G-H. Plots showing the percentage of anastasis normalized to the control in cells treated 5h with 150ng/ml (A, D, G) or 250ng/ml DOX (B, E, H), and washed with different concentrations of the Akt inhibitor ALM301 (A, B), the PI3K inhibitor LY29004 (D, E), or the dual EGFR/PI3K inhibitor MTX-531 (G, H). Although 100µM MTX-531 is the most lethal condition, the plotted curve does not fully capture this effect because extensive cell death led to aggregation, which interfered with accurate detection of anastatic cells and artificially increased their measured frequency (G-H, *Artifact). Different treatments are shown in distinct colors. The positive control (qVD-Oph) is shown in black. Data were normalized by subtraction. Data and error bars were smoothed. Error bars represent the mean ± SD from n=2 independent experiments. C. Plot showing the percentage confluence normalized to its initial value in cells that were not exposed to DOX for ALM301 treatment. F, I. Images comparing the effects of 10µM and 100µM LY294002 (F) or MTX-531 (I) and the corresponding DMSO controls in cells that were not exposed to DOX at the end of our experiment.
    Figure Legend Snippet: A-B, D-E, G-H. Plots showing the percentage of anastasis normalized to the control in cells treated 5h with 150ng/ml (A, D, G) or 250ng/ml DOX (B, E, H), and washed with different concentrations of the Akt inhibitor ALM301 (A, B), the PI3K inhibitor LY29004 (D, E), or the dual EGFR/PI3K inhibitor MTX-531 (G, H). Although 100µM MTX-531 is the most lethal condition, the plotted curve does not fully capture this effect because extensive cell death led to aggregation, which interfered with accurate detection of anastatic cells and artificially increased their measured frequency (G-H, *Artifact). Different treatments are shown in distinct colors. The positive control (qVD-Oph) is shown in black. Data were normalized by subtraction. Data and error bars were smoothed. Error bars represent the mean ± SD from n=2 independent experiments. C. Plot showing the percentage confluence normalized to its initial value in cells that were not exposed to DOX for ALM301 treatment. F, I. Images comparing the effects of 10µM and 100µM LY294002 (F) or MTX-531 (I) and the corresponding DMSO controls in cells that were not exposed to DOX at the end of our experiment.

    Techniques Used: Control, Positive Control



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    A-B, D-E, G-H. Plots showing the percentage of anastasis normalized to the control in cells treated 5h with 150ng/ml (A, D, G) or 250ng/ml DOX (B, E, H), and washed with different concentrations of the Akt inhibitor ALM301 (A, B), the PI3K inhibitor LY29004 (D, E), or the dual EGFR/PI3K <t>inhibitor</t> <t>MTX-531</t> (G, H). Although 100µM MTX-531 is the most lethal condition, the plotted curve does not fully capture this effect because extensive cell death led to aggregation, which interfered with accurate detection of anastatic cells and artificially increased their measured frequency (G-H, *Artifact). Different treatments are shown in distinct colors. The positive control (qVD-Oph) is shown in black. Data were normalized by subtraction. Data and error bars were smoothed. Error bars represent the mean ± SD from n=2 independent experiments. C. Plot showing the percentage confluence normalized to its initial value in cells that were not exposed to DOX for ALM301 treatment. F, I. Images comparing the effects of 10µM and 100µM LY294002 (F) or MTX-531 (I) and the corresponding DMSO controls in cells that were not exposed to DOX at the end of our experiment.
    Mtx 531, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 94/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/mtx 531/product/MedChemExpress
    Average 94 stars, based on 1 article reviews
    mtx 531 - by Bioz Stars, 2026-03
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    A-B, D-E, G-H. Plots showing the percentage of anastasis normalized to the control in cells treated 5h with 150ng/ml (A, D, G) or 250ng/ml DOX (B, E, H), and washed with different concentrations of the Akt inhibitor ALM301 (A, B), the PI3K inhibitor LY29004 (D, E), or the dual EGFR/PI3K <t>inhibitor</t> <t>MTX-531</t> (G, H). Although 100µM MTX-531 is the most lethal condition, the plotted curve does not fully capture this effect because extensive cell death led to aggregation, which interfered with accurate detection of anastatic cells and artificially increased their measured frequency (G-H, *Artifact). Different treatments are shown in distinct colors. The positive control (qVD-Oph) is shown in black. Data were normalized by subtraction. Data and error bars were smoothed. Error bars represent the mean ± SD from n=2 independent experiments. C. Plot showing the percentage confluence normalized to its initial value in cells that were not exposed to DOX for ALM301 treatment. F, I. Images comparing the effects of 10µM and 100µM LY294002 (F) or MTX-531 (I) and the corresponding DMSO controls in cells that were not exposed to DOX at the end of our experiment.
    Mtx 531, supplied by WuXi AppTec, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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    Image Search Results


    A-B, D-E, G-H. Plots showing the percentage of anastasis normalized to the control in cells treated 5h with 150ng/ml (A, D, G) or 250ng/ml DOX (B, E, H), and washed with different concentrations of the Akt inhibitor ALM301 (A, B), the PI3K inhibitor LY29004 (D, E), or the dual EGFR/PI3K inhibitor MTX-531 (G, H). Although 100µM MTX-531 is the most lethal condition, the plotted curve does not fully capture this effect because extensive cell death led to aggregation, which interfered with accurate detection of anastatic cells and artificially increased their measured frequency (G-H, *Artifact). Different treatments are shown in distinct colors. The positive control (qVD-Oph) is shown in black. Data were normalized by subtraction. Data and error bars were smoothed. Error bars represent the mean ± SD from n=2 independent experiments. C. Plot showing the percentage confluence normalized to its initial value in cells that were not exposed to DOX for ALM301 treatment. F, I. Images comparing the effects of 10µM and 100µM LY294002 (F) or MTX-531 (I) and the corresponding DMSO controls in cells that were not exposed to DOX at the end of our experiment.

    Journal: bioRxiv

    Article Title: A kinome inhibitor screen implicates adhesion and growth factor signaling in cellular recovery after caspase activation

    doi: 10.64898/2026.01.06.697929

    Figure Lengend Snippet: A-B, D-E, G-H. Plots showing the percentage of anastasis normalized to the control in cells treated 5h with 150ng/ml (A, D, G) or 250ng/ml DOX (B, E, H), and washed with different concentrations of the Akt inhibitor ALM301 (A, B), the PI3K inhibitor LY29004 (D, E), or the dual EGFR/PI3K inhibitor MTX-531 (G, H). Although 100µM MTX-531 is the most lethal condition, the plotted curve does not fully capture this effect because extensive cell death led to aggregation, which interfered with accurate detection of anastatic cells and artificially increased their measured frequency (G-H, *Artifact). Different treatments are shown in distinct colors. The positive control (qVD-Oph) is shown in black. Data were normalized by subtraction. Data and error bars were smoothed. Error bars represent the mean ± SD from n=2 independent experiments. C. Plot showing the percentage confluence normalized to its initial value in cells that were not exposed to DOX for ALM301 treatment. F, I. Images comparing the effects of 10µM and 100µM LY294002 (F) or MTX-531 (I) and the corresponding DMSO controls in cells that were not exposed to DOX at the end of our experiment.

    Article Snippet: We used ALM301 (CAS #1313439-71-2) to inhibit Akt (cat#HY-151504, MedChemExpress) , LY294002 (CAS #154447-36-6) to inhibit PI3K (cat#PHZ1144, Thermo Fisher Scientific) ( , ), MTX-531 (CAS #2791417-66-6) to inhibit EGFR/PI3K (cat#43038, Cayman Chemicals) , and rapamycin (CAS #53123-88-9) to inhibit mTOR (cat#HY-10219, MedChemExpress) ( ).

    Techniques: Control, Positive Control